Invasive Breast Cancer:
Relationship between Shear-wave Elastographic Findings and Histologic
Prognostic Factors
Purpose: To compare the
histologic prognostic feature of invasive breast cancer with mean stiffness as
measured with shear-wave elastography.
Materials and Methods:
This retrospective study was exempted from ethical committee review. Patient
consent for use of images for research was obtained. The study group comprised
101 consecutive women (age range, 38–91 years) with solid lesions identified
during routine breast ultrasonography (US) performed between April 2010 and
March 2011 and subsequently confirmed at histologic examination to be invasive
cancers. Four elastographic images in two orthogonal planes were obtained of
each lesion, and mean stiffness values were obtained from each image.
Histologic findings following surgery were used for comparison, namely
histologic grade, tumor type, invasive size, vascular invasion status, and
lymph node status. Relationship between mean stiffness and histologic
parameters was investigated by using a general linear model and multiple
regression analysis.
Results: High histologic
grade (P < .0001), large invasive size (P < .0001), lymph node involvement (P < .0001), tumor type (P < .0001), and vascular invasion (P = .0077) all showed statistically significant
positive association with high mean stiffness values. Multiple linear
regression indicated that invasive size is the strongest pathologic determinant
of mean stiffness (P < .0001),
with histologic grade also having significant influence (P = .022).
Conclusion: In this
study, breast cancers with higher mean stiffness values at shear-wave
elastography had poorer prognostic features.
© RSNA, 2012
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