In her thesis, Jeanette Hansson discusses two major clinical studies of
adult patients with acute appendicitis. In the first study she compares surgery
with antibiotic therapy, while in the second patients with appendicitis were
treated with antibiotics as first-line therapy.
Carried out at Sahlgrenska University Hospital
and Kungälv Hospital
"Some patients are so ill that the operation is absolutely
necessary, but 80 percent of those who can be treated with antibiotics recover
and return to full health," says Jeanette Hansson.
The thesis also shows that patients who are treated with antibiotics
are at risk of fewer complications than those who undergo surgery.
The risk of recurrence within 12 months of treatment with antibiotics
is around 10-15 percent. Jeanette Hansson and her colleagues hope to be able to
document the risk of recurrence over the long term and also to study whether
recurrences can also be treated with antibiotics.
Even though increased resistance to antibiotics could also affect the
treatment, the conclusion is that antibiotics are a viable alternative to
surgery in adult patients as things stand, provided that the patient accepts
the risk of recurrence.
"It's important to note that our studies show that patients who
need surgery because of recurrences, or because the antibiotics haven't worked,
are not at risk of any additional complications relative to those operated on
in the first place," says Jeanette Hansson.
The thesis: "Antibiotic therapy as single treatment of acute
appendicitis" was publicly defended in May.
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