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Microcalcifications are not easily detectable by US, particularly when they are not associated with a mass, but rather lie within normal breast tissue . Because microcalcifications (at around 200 µm) are so small, normal fibroglandular tissues or US speckle artifacts interfere with their visualization. Therefore, mammography-guided tissue diagnoses should be performed for grouped microcalcifications with suspicious morphology.

ABSTRACT:
The term "grouped microcalcifications" refers to the smallest arrangement of a relatively few calcifications noted on mammography, and has a wide range of clinical associations. For the pathologic diagnosis of suspicious-looking grouped microcalcifications without an associated mass, a mammography-guided procedure should be considered, because visualization of microcalcifications by conventional ultrasound (US) is limited. A mammography-guided procedure requires radiation exposure, is associated with pain, and is more time-consuming to perform than an US-guided procedure. However, an innovative US technology called MicroPure™ (Toshiba Medical Systems Corp., Tokyo, Japan) imaging improves detection and visualization of microcalcifications. We demonstrate the early clinical experience with and utility of MicroPure US examination of 10 breast lesions involving grouped microcalcifications without a mass on mammography screening.